Vorlesungen im Rahmen von Bachelor/Master Studiengängen.

Hematopoiesis

Overview hematopoiesis

Excursion: Cytokines, lymphokines, growth factor networks

Bone marrow stem cells and stem cell niches

Red blood cells

Overview leukocytes

Lymphocytes, T-/B-/NK cells

Granulocytes, monocytes, macrophages, dendritic cells

Megakaryocytes, platelets

Pathophysiology of the immune/blood system: examples

In vitro cell culture bone marrow stem cells, hematopoietic cells

Physiology and genetics of iron metabolism

Physiological in vivo relevance of iron

Iron in heme proteins

Overview regulation of erythropoiesis

Overview proteins involved in iron metabolism

Iron uptake and transport from intestine

Iron transport in blood and cellular uptake via transferrin receptor

Intracellular iron sensors and iron storage

Function and expression regulation of the iron channel ferroportin

Genetics of iron metabolism relevant genes

Disorders of iron deficiency and iron overload

Chemical/biochemical pathophysiology of iron overload: the Fenton reaction

Cellular iron loss and in vitro toxicity